Monday, June 6, 2011

The Squid Giant Synapse: A Model for Chemical Transmission Review

The Squid Giant Synapse: A Model for Chemical Transmission
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Review of "The Squid Giant Synapse" a model for chemicaltransmission" by Rodolfo R. Llinas.
It was a pleasure to read thissmall book because Professor Llinas has managed to review his work and thatof others within 160 pages.Llinas has written a very readable book thattraces the history of transmission at the synapse.He has covered thisdifficult subject synthesizing ultrastructure, electrophysiology andmolecular biology.The writer has been prominent in this field for 30years and the book reflects his deep understanding of the subject.Dr.Llinas has managed to incorporate the major findings of some 500 papersinto a working hypothesis of synaptic transmission.In spite of thecomplexity of the subject there are few errors.On page 65 microdomainsshould be in square microns and not square millimeters but thistypographical error should be obvious when looking at Figure 3.2G and Plate8.This little book is a must for graduate students and neuroscientists ingeneral because it serves as both a starting reference and as a workingtext. The index is very helpful to find definitions used in the field (aglossary would be helpful).The soft ware shows the relationship of thepresynaptic calcium current and postsynaptic voltage.This program will beinstructive to students in understanding the importance of calciumdependencies on transmitter release.The Squid Giant Synapse should be acompanion with Nerve, Muscle and Synapse by B.Katz and The Physiology ofSynapses by J.C. Eccles.

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Product Description:
The squid giant synapse has historically been the best model for investigating synaptic transmission. This book gives a concise overview of all that has been learned from this model. Ideal for graduate and undergraduate courses, the book includes PC and Macintosh versions of a program for simulating and manipulating any aspect of synaptic transmission.

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