Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Tuesday, September 27, 2011

Memory and Emotion: The Making of Lasting Memories Review

Memory and Emotion:  The Making of Lasting Memories
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One of the faculties of mind that is extremely puzzling is our capacity to remember.Jane Austen knew this.In _Mansfield Park_, she wrote, "If any one faculty of our nature may be called more wonderful than the rest, I do think it is memory...We are, to be sure, a miracle every way; but our powers of recollecting and of forgetting do seem peculiarly past finding out."Past finding out two hundred years ago, yes, and not nearly fully found out now, but memory is gradually yielding its secrets.James L. McGaugh is the director of the Center for the Neurobiology of Learning and Memory at the University of California, and he has written a primer, _Memory and Emotion: The Making of Lasting Memories_ (Columbia University Press), which is a fine summary of how some of the mysteries of memory are being tackled.He has written "for a general readership" (the book is in the "Maps of the Mind" series), but the subject will be a foreign one for most readers, and there are pithy pages that his general readers may have to struggle through.For the most part, though, McGaugh tells good anecdotes and admirably makes clear some of the most hidden of mental processes, and the explanations help us wonder anew at the remarkable capacities that every one of us takes for granted.
It is certainly a field in which people are interested.There are plenty of books with titles like _Boost Your Memory Now_, and the health stores do a fine business in herbal treatments that are supposed to make our memories better, with little evidence they work.There may be drugs that improve specific memories, however, or decrease their consolidation.Much of the research has been done on rats; evolutionarily, their brains wound up much like ours, just smaller and less complex.Rats can be trained to do such memory-requiring tasks as maze-running and then can be fiddled with in ways that humans cannot.Such drugs as strychnine, a central nervous system stimulant, can be given immediately _after_ maze training (that is, after all the learning exercise has been done), and the rats remember better what they learned during the training.Giving the strychnine hours after the training does nothing; the brains must have a consolidation phase during which the memory is laid down.Other experiments show that a drug like propranolol, used to lower blood pressure because it counteracts the body's store of epinephrine (also known as adrenaline), can counteract epinephrine's capacity to help consolidate memories.Giving propranolol after an emotional memory test blocks the enhancement boost that emotion gives to memory.This is not an academic exercise.Emergency room victims of trauma, if given propranolol, are less likely to have symptoms of post-traumatic stress disorder.
In such ways is memory yielding its secrets.In his review, McGaugh quite rightly refers to the important work of Susan Loftus that shows that false memories can be implanted, especially in children.If you go to a family reunion, it does not take long to learn that some people remember important events one way, and others another contradictory way, but the memories are really there, false or not.Implanting such seemingly real memories is the way that bogus therapists convince their patients that, say, they have received Satanic abuse as children.Eyewitness testimony has been shown to be terribly fallible, now that we have video cameras and DNA testing.But McGaugh and others have been able to discover some secrets about how generally reliable a servant memory is and how it is able to do its job.His volume allows us the pleasing exercise of picking up from a leader in the field just how much research has been accomplished, and of catching a bit of his enthusiasm for his work.

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Tuesday, August 16, 2011

Physics of Optoelectronic Devices (Wiley Series in Pure and Applied Optics) Review

Physics of Optoelectronic Devices
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The book starts with the very basic equations of electromagnetic and semiconductor theory and builds up to more advanced topics such as band structure calculations for semiconductors including strained quantum wells,various optical transitions processes, optical absorption spectra, etc.Inaddition, the book covers the basic theory of laser cavity resonance andthis includes the distributed feedback laser theory.Various waveguide,electro-optical modulators and photodetector principles are also treated inclear detail.The book brings you up to the level of which the researchpapers in the optoelectronic area has been written.

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Emphasizes the theory of semiconductor optoelectronic devices, demonstrating comparisons between theoretical and experimental results. Presents such important topics as semiconductor heterojunctions and band structure calculations near the band edges for bulk and quantum-well semiconductors. Details semiconductor lasers including double-heterostructure, stripe-geometry gain-guided semiconductor, distributed feedback and surface-emitting. Systematically investigates high-speed modulation of semiconductor lasers using linear and nonlinear gains. Features new subjects such as the theories on the band structures of strained semiconductors and strained quantum-well lasers. Covers key areas behind the operation of semiconductor lasers, modulators and photodetectors.

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Tuesday, March 1, 2011

Introduction to Spintronics Review

Introduction to Spintronics
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In signal processing, power, computing systems and circuits the use of spin in place of charge is going to get used and thus improve of speed, power consumption, and device density is now possible in micro- and nano-electronics.

Introduction to Spintronics is an accessible, organized, and progressive presentation of the quantum mechanical concept of spin covering active hybrid spintronic devices, monolithic spintronic devices, passive spintronic devices, and devices based on the giant magneto-resistance effect. The concepts of spin logic gates in Quantum Computation is really a fascinating ride given by the authors. Finally, "A Quantum Mechanical Primer" has rich the book to a level of best.

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Using spin to replace or augment the role of charge in signal processing devices, computing systems and circuits may improve speed, power consumption, and device density in some cases—making the study of spinone of the fastest-growing areas in micro- and nanoelectronics. With most of the literature on the subject still highly advanced and heavily theoretical, the demand for a practical introduction to the concepts relating to spin has only now been filled.
Explains effects such as giant magnetoresistance, the subject of the 2007 Nobel Prize in physics
Introduction to Spintronics is an accessible, organized, and progressive presentation of the quantum mechanical concept of spin. The authors build a foundation of principles and equations underlying the physics, transport, and dynamics of spin in solid state systems. They explain the use of spin for encoding qubits in quantum logic processors; clarify how spin-orbit interaction forms the basis for certain spin-based devices such as spintronic field effect transistors; and discuss the effects of magnetic fields on spin-based device performance.
Covers active hybrid spintronic devices, monolithic spintronic devices, passive spintronic devices, and devices based on the giant magnetoresistance effect
The final chapters introduce the burgeoning field of spin-based reversible logic gates, spintronic embodiments of quantum computers, and other topics in quantum mechanics that have applications in spintronics. An Introduction to Spintronics provides the knowledge and understanding of the field needed to conduct independent research in spintronics.

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Sunday, February 13, 2011

Drug Discovery: A History Review

Drug Discovery: A History
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This book answers so many questions about where medications come from. Drug discovery has a rich history, and it is difficult to find any information. This book is fantastic!!
VC RPh

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Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.
This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society.
Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research.
Hallmark features:

    Up-to-the-minute information in drug research
    Vignettes of special and unusual information, and anecdotes
    Discusses drug prototypes from all sources
    More comprehensive than other volumes on history of drug discovery

From the reviews:
"...an excellent bibliographic resource for those interested in the background papers that serve as the foundation for discovery of specific drug entities." JOURNAL OF MEDICAL CHEMISTRY, June 2006
"...a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." JOURNAL OF CHEMICAL EDUCATION, February 2006
"...a very readable and closely researched book..." CHEMISTRY & INDUSTRY, October 2005

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Friday, February 11, 2011

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists Review

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
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The text covers the practical application of PK/PD and metabolism; while targeted at industrial scientists, I found material to be equally appropriate for academics at all who are interested in pharmacology.

The nice thing about this test is it it clearly organized, and very direct - providing exactly what the title states.

If you have much background in PK/PD/Metabolism, this text might not be for you.

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Bioneer Life Science, San Diego, CA. Designed for industrial scientists, laboratory assistants, and managers involved in PK/PD.DM-related areas. Each chapter deals with a particular issue and its industrial applications. Expanded-outline format.

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Saturday, January 8, 2011

Advances in the Neuroscience of Addiction (Frontiers in Neuroscience) Review

Advances in the Neuroscience of Addiction
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this is an excellent review of the current understanding of the brain systems and chemistry involved with addiction. A knowledge of neuroanatomy and neurochemistry as well as genetics is presumed.

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Monday, October 18, 2010

Applied Biopharmaceutics & Pharmacokinetics (Shargel, Applied Biopharmaceuticals & Pharmacokinetics) Review

Applied Biopharmaceutics & Pharmacokinetics
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There are so many mistakes in this book, average 1 per page in the math formulas, in the answer pages.Things don't match up.Did anyone bother editing this book?I can't believe thenumber of mistakes.

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Product Description:
Applied Biopharmaceutics and Pharmacokinetics provides the reader with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. The revised and updated fifth edition of this popular text remains unique in teaching the student the basic concepts that may be applied to understanding the complex issues associated with the processes of drug delivery and the essentials of safe and effective drug therapy.
NEW TO THIS EDITION:
*Chapter on Pharmacogenetics
*Explanation of the role of pharmacogenetics in drug metabolism using examples of drugs that frequently lead to drug interactions
*Chapter on the Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy
*Enhanced applications to pharmacy practice with the emphasis on biopharmaceutics, pharmacokinetics and drug delivery
*Updated coverage of dosing in clinical situations including dosing in special populations and what to do with a skipped dose in patients
*Additional practice problems and clinical examples
*Newest concepts in biopharmaceutics and pharmacokinetics
*Reorganized content to follow today's curriculum in pharmaceutical sciences

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