Showing posts with label brain. Show all posts
Showing posts with label brain. Show all posts

Tuesday, September 27, 2011

Memory and Emotion: The Making of Lasting Memories Review

Memory and Emotion:  The Making of Lasting Memories
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One of the faculties of mind that is extremely puzzling is our capacity to remember.Jane Austen knew this.In _Mansfield Park_, she wrote, "If any one faculty of our nature may be called more wonderful than the rest, I do think it is memory...We are, to be sure, a miracle every way; but our powers of recollecting and of forgetting do seem peculiarly past finding out."Past finding out two hundred years ago, yes, and not nearly fully found out now, but memory is gradually yielding its secrets.James L. McGaugh is the director of the Center for the Neurobiology of Learning and Memory at the University of California, and he has written a primer, _Memory and Emotion: The Making of Lasting Memories_ (Columbia University Press), which is a fine summary of how some of the mysteries of memory are being tackled.He has written "for a general readership" (the book is in the "Maps of the Mind" series), but the subject will be a foreign one for most readers, and there are pithy pages that his general readers may have to struggle through.For the most part, though, McGaugh tells good anecdotes and admirably makes clear some of the most hidden of mental processes, and the explanations help us wonder anew at the remarkable capacities that every one of us takes for granted.
It is certainly a field in which people are interested.There are plenty of books with titles like _Boost Your Memory Now_, and the health stores do a fine business in herbal treatments that are supposed to make our memories better, with little evidence they work.There may be drugs that improve specific memories, however, or decrease their consolidation.Much of the research has been done on rats; evolutionarily, their brains wound up much like ours, just smaller and less complex.Rats can be trained to do such memory-requiring tasks as maze-running and then can be fiddled with in ways that humans cannot.Such drugs as strychnine, a central nervous system stimulant, can be given immediately _after_ maze training (that is, after all the learning exercise has been done), and the rats remember better what they learned during the training.Giving the strychnine hours after the training does nothing; the brains must have a consolidation phase during which the memory is laid down.Other experiments show that a drug like propranolol, used to lower blood pressure because it counteracts the body's store of epinephrine (also known as adrenaline), can counteract epinephrine's capacity to help consolidate memories.Giving propranolol after an emotional memory test blocks the enhancement boost that emotion gives to memory.This is not an academic exercise.Emergency room victims of trauma, if given propranolol, are less likely to have symptoms of post-traumatic stress disorder.
In such ways is memory yielding its secrets.In his review, McGaugh quite rightly refers to the important work of Susan Loftus that shows that false memories can be implanted, especially in children.If you go to a family reunion, it does not take long to learn that some people remember important events one way, and others another contradictory way, but the memories are really there, false or not.Implanting such seemingly real memories is the way that bogus therapists convince their patients that, say, they have received Satanic abuse as children.Eyewitness testimony has been shown to be terribly fallible, now that we have video cameras and DNA testing.But McGaugh and others have been able to discover some secrets about how generally reliable a servant memory is and how it is able to do its job.His volume allows us the pleasing exercise of picking up from a leader in the field just how much research has been accomplished, and of catching a bit of his enthusiasm for his work.

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Friday, May 20, 2011

Clinical Neuromythology and Other Arguments and Essays, Pertinent and Impertinent Review

Clinical Neuromythology and Other Arguments and Essays, Pertinent and Impertinent
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This is one of the best books I have ever encountered about practical neurology.As one of the house officers to Dr. Landau, and after the passage of time, I remember clearly his logic when rounding with him and discussing patients in the morning.Even during my oral examination, soon to be defunct, I still remembered his words:"The history is everything"."How do you know if the patient is telling or not the truth"."What this patient needs is a good doctor that will take care of him after he leaves the hospital"What can you do for this guy, how can we help him?

Dr. Landau's book is full of vignettes.I vouch for the veracity of the vignettes, as one of the many that have faced his inquisitive mind after a long night on-call at Barnes Hospital.Clinical Neuromythology is organized to reflect the actual cases a house officer will encounter while working in the hospital.It mainly deals with myths in neurology as they are transferred from generation to generation of neurologists, sometimes without much evidence to support them.Dr. Landau squarely attacks the classical approach to spasticity, the public efforts to "degrease" americans without paying attention to the role of obesity and other more important factors; the fiasco of the Deprenyl studies in Parkinson disease; the believe that dorsal rhizotomy is evidence-based when the treatment is actually of unproven efficacy, and much more.I highly recommend this book for all those who are involved in the decision-making process to treat patients in the field of Neurology.It will make you think twice whether your decisions are based on mythology or reality.

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Announcing the forthcoming publication of the enlarged edition of Clinical Neuromythology and Other Arguments and Essays, Pertinent and Impertinent, Updated Edition by William M. Landau, MD.Due to the success of the first edition, new material has been added.A major new section concerning pain and pain management addresses the confusion of temperomandibular pain and the efficacy and risk of intraspinal steroid treatment.Updated controversy about treatment for parkinsonism includes the failure of embryonic brain transplantation and the success of electrical brain stimulation.The slippery controversies regarding dietary fat, the obesity epidemic, cholesterol, stroke risk and treatment are described, and attention is directed to the fact that the popular extension of cardiopulmonary resuscitation equipment will produce dementia in a large proportion of survivors.The book is being re-issued in paperback at a special price.

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Sunday, March 27, 2011

Surgical Neuroangiography Review

Surgical Neuroangiography
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The whole work Surgical Neuroangiography by P Lasjaunias is a monument. While the first edition did not really reflect the brilliant mind that Prof Lasjaunias was, it was indispensable. In many ways the new edition is even better, much much better even since much of the sometimes confounding structure of the rpevious version has been improved and the book can now be used to really learn neuroangiography. Indeed the rpevious version, while containing information of extreme importance was very (very) difficult to read. The new version is rather easy and very very enjoyable since it provides great insight to the work of what was one of the giants of Neuroradiology whose lectures will be sadly missed.

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This book will be helpful to professionals who use the vascular system of the spine, spinal cord, and brain in their practice and in their search for better understanding, reliability, and safety in their decisions and actions by providing a new conceptual approach to the vascular supply to the brain spine and spinal cord. Statements such as "the median cerebral artery is a branch of the anterior cerebral artery" or "the internal carotid and vertebral arteries are minor vessels, they can be absent. They represent the most common distribution pattern to the arterial circle at the base of the brain, but certainly not the only one" show that the authors are far from providing the traditional presentation of the arterial system in man.

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